This medication may rarely cause problems. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. The main sign that you have this condition is very high levels of total cholesterol and LDL cholesterol. For instance, you may have a total cholesterol level of 600 points or higher. By comparison, the American Heart Association recommends the ideal total cholesterol number be less than 180.
Some MEDICINES MAY INTERACT with ezetimibe. Cholesterol is waxy stuff that's in your cells. 's job is to carry cholesterol around your body in your bloodstream. If you experience unexplained muscle pain, weakness, or tenderness, contact your doctor.
Schering-Plough. Vytorin ezetimibe and simvastatin tablets prescribing information. Get a lower dosage. If you smoke, it's time to quit. Set a date and talk to your doctor. If you've tried to quit before, it's not too late. Many people try several times before they kick the habit for good.
Do you have any chest pain? Simvastatin has been associated with rare cases of severe myopathy and rhabdomyolysis. This is accompanied by elevations in creatine kinase, myoglobinuria, and proteinuria, as well as renal failure. Experience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozil, niacin, cyclosporine, or erythromycin may increase the incidence and the severity of musculoskeletal side effects. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as any concomitant illnesses.
Moderate or severe hepatic impairment: Do not use. This information should not be used to decide whether or not to take ezetimibe or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about ezetimibe. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to ezetimibe. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using ezetimibe. Moderate. These medicines may cause some risk when taken together. Use ezetimibe as directed by your doctor. Check the label on the medicine for exact dosing instructions. Lab tests, including liver function and cholesterol levels, may be performed while you use ezetimibe. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. For some people, this treatment still won't keep cholesterol under control. Weise WJ, Possidente CJ "Fatal rhabdomyolysis associated with simvastatin in a renal transplant patient. Try to every day, which also will help control your cholesterol levels. In rare cases, cholesterol-lowering medication can cause a condition that results in the breakdown of skeletal muscle tissue. This condition can lead to kidney failure. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. Combination therapy with a statin or fenofibrate: May administer ezetimibe at same time as the statin or fenofibrate, in accordance with recommended dosing schedule for these drugs.
Have you ever noticed that you're short of breath? Diarrhea; dizziness; mild cough or sore throat; runny or stuffy nose. Ezetimibe should not be used in CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed. Grundy SM "Can statins cause chronic low-grade myopathy? Peter Kim, president of Merck Research Laboratories, which makes Zetia, says the new study w as limited due to its small size and short length. "It would be very unfortunate if a flawed analysis led patients to discontinue their cholesterol treatment. telmisartan
Other medications can affect the removal of simvastatin from your body, which may affect how simvastatin works. Examples include certain azole antifungals such as itraconazole, ketoconazole, posaconazole, voriconazole boceprevir, cobicistat, colchicine, delavirdine, macrolide antibiotics such as clarithromycin, erythromycin nefazodone, HIV protease inhibitors such as nelfinavir, ritonavir telaprevir, telithromycin, among others. The study was halted in July, about four months early, when investigators concluded that one group was clearly doing better than the other -- although they did not say which group was doing better at the time; 208 patients completed the trial. Risk of myopathy; importance of promptly informing clinicians of unexplained muscle pain, weakness, or tenderness. If you also take certain other drugs to lower your bile acid-binding resins such as or take this product at least 2 hours before or at least 4 hours after taking these medications. These medications can react with this product, preventing its full absorption. Food and Drug Administration. Walker JF "Simvastatin: the clinical profile. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Take a brief break. The dosage is based on your medical condition and response to treatment. What is the most important information I should know about ezetimibe Zetia? This drug may increase the risk of liver damage when taken with a "statin" or muscle damage when taken with a fibrate or "statin". Sinzinger H, Wolfram R, Peskar BA "Muscular side effects of statins. Store at room temperature between 68-77 degrees F 20-25 degrees C away from light and moisture. not store in the bathroom. Keep all medicines away from children and pets. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. About half of the patients were given Niaspan and the other half were given Zetia, in addition to their usual statin drugs. amitriptyline order online payment usa amitriptyline
PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using ezetimibe while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use ezetimibe, check with your doctor. Discuss any possible risks to your baby. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. It is unknown if this medication passes into milk. However, similar drugs pass into milk. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding. If you also take a bile acid sequestrant eg, cholestyramine, colesevelam, colestipol do not take it within 4 hours before or 2 hours after taking ezetimibe. Check with your doctor if you have questions. Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort. New England Journal of Medicine. Ezetimibe may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. Anaphylaxis, angioedema, rash, and urticaria reported. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. If drugs and diet aren't helping, there's another treatment that takes blood from your body, removes the cholesterol, and then returns the blood back to you. Take this by with or without food as directed by your doctor, usually once daily in the evening. Feldmann R, Mainetti C, Saurat JH "Skin lesions due to treatment with simvastatin Zocor. ASCVD risk reduction benefits compared to their potential for adverse effects in the routine prevention of ASCVD. No differences in pharmacokinetic parameters between blacks and Caucasians. 1 Studies in Asian individuals indicated similar pharmacokinetics as observed in Caucasian individuals. Contact your doctor or health care provider right away if any of these apply to you. awweb.info cipro
He may need to try different combinations of drugs and treatments until he finds one that works best for you. Talk with your doctor or pharmacist if you have questions about effective birth control. The disease raises your chances of a at an early age, but drugs and other treatments can lower your risk. Approximately 93% of dose is absorbed systemically following oral administration. Check with your pharmacist about how to dispose of unused medicine. Mild hepatic impairment: No dosage adjustment needed. Gagne C, Bays HE, Weiss SR et al for the Ezetimibe Study Group. Efficacy and safety of ezetimibe added to ongoing statin therapy for treatment of patients with primary hypercholesterolemia. Am J Cardiol. Retrieved 15 July 2016. Inc. Vytorin ezetimibe and simvastatin tablets prescribing information. Whitehouse Station, NJ; 2012 Jun. At a news conference at the AHA meeting Sunday night, Taylor reported that the "winner" was Niaspan. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Nakad A, Bataille L, Hamoir V, Sempoux C, Horsmans Y "Atorvastatin-induced acute hepatitis with absence of cross-toxicity with simvastatin. C. 1 Protect from moisture. Use in combination with fenofibrate as an adjunct to dietary therapy to decrease elevated serum total cholesterol, LDL-cholesterol, apo B, and non-HDL-cholesterol concentrations in the treatment of mixed dyslipidemia. 1 Effects on cardiovascular morbidity and mortality not established. 1 Use with a fibric acid derivative other than fenofibrate not studied and currently not recommended. 1 See Specific Drugs under Interactions. SJS Basha; SA Naveed; NK Tiwari; D Shashikumar; S Muzeeb; TR Kumar; NV Kumar; NP Rao; N Srinivas; M Ramesh; NR Srinivas 2007. "Mechanism of Drug-Drug Interactions Between Warfarin and Statins". Talk to your pharmacist if you have questions about this information. order now fosamax store
Bjerre LM, LeLorier J "Do statins cause cancer? How do you check if my treatment is working? Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Chariot P, Abadia R, Agnus D, Danan C, Charpentier C, Gherardi RK "Simvastatin-induced rhabdomyolysis followed by a MELAS syndrome. Ezetimibe may be taken at the same time with Antara, Lipofen, Lofibra, TriCor, Triglide or with any of the "statin" drugs such as Mevacor Zocor Pravachol Lescol Lipitor or cerivastatin Baycol. It is important to continue taking this medication even if you feel well. Most people with high cholesterol do not feel sick. It may take up to 2 weeks before you get the full benefit of this drug. However, they all had suboptimal HDL levels. Do not take 2 doses at once. When used in fixed combination with simvastatin, consider drug interactions associated with simvastatin. 12 No formal drug interaction studies to date with fixed-combination preparation other than that with extended-release niacin. 20 See Specific Drugs under Interactions. Bannwarth B, Miremont G, Papapietro PM "Lupuslike syndrome associated with simvastatin. CHILDREN; safety and effectiveness in children have not been confirmed. Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with or do not feel sick. European Atherosclerosis Society, the Japan Atherosclerosis Society, the National Institute for Health and Clinical Excellence, and the International Atherosclerosis Society recommend ezetimibe as one of several second line treatment options for people who are intolerant of statins or who are unable to reach serum LDL goals using statins alone. Do your parents have high cholesterol? If you also take certain other drugs to lower your cholesterol bile acid-binding resins such as cholestyramine or colestipol take this product at least 2 hours before or at least 4 hours after taking these medications. These medications can react with this product, preventing its full absorption. Inc. Zetia ezetimibe tablets prescribing information. Whitehouse Station, NJ; 2013 Aug.
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RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Stone NJ, Robinson JG, Lichtenstein AH, et al. June 2014. Schering-Plough, PA: Personal communication. Following oral administration, ezetimibe is absorbed and extensively conjugated to a phenolic glucuronide active metabolite. discount finasteride forum
Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection. Yurdakok M, Gurakan B, Ergin H, Kirazli S "Plasma concentrations of granulocyte colony stimulating factor in preterm infants in the first few hours of life. Does not inhibit or induce CYP1A2, 2D6, 2C8, 2C9, or 3A4. You may have a blood test to look for the abnormal gene that causes this condition. Your doctor might also want to test some of your close relatives to see if they have the disease. Ezetimibe is primarily metabolized in the liver and the small intestine via glucuronide conjugation with subsequent renal and biliary excretion. Both the parent compound and its active metabolite are eliminated from plasma with a half-life around 22 hours, allowing for once-daily dosing. Ezetimibe lacks significant inhibitor or inducer effects on isoenzymes, which explains its limited number of drug interactions.
Administer orally without regard to meals. Duits N, Bos FM "Depressive symptoms and cholesterol-lowering drugs. When used in combination or fixed combination with a statin or fenofibrate, consult prescribing information of specific statin or fenofibrate for detailed information on usual cautions, precautions, and contraindications of these drugs. topiramate
Yellowish fat deposits called xanthelasmas can develop in your eyelids. Read the Patient Information Leaflet if available from your pharmacist before you start taking this product and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Do not remove the tablet from the tablet pack until you are ready to take this drug. Take the tablet right away after opening the blister pack. Do not store the removed tablet for future use. Ezetimibe is to be used only by the patient for whom it is prescribed. Do not share it with other people. sotalol